Resistant Hypertension

High blood pressure treatment

What is resistant hypertension?

Resistant hypertension is high blood pressure that is not controlled despite the use of at least three medications.

High blood pressure is a blood pressure of ≥140 mmHg systolic and ≥ 90 mmHg diastolic.

Resistant hypertension is defined as high blood pressure that does not respond to treatment with at least three medications.[1] According to the American Heart Association (AHA), of 74 million American adults with high blood pressure, 48 percent do not adequately control the condition. Globally, one in 10 people with high blood pressure, or nearly 100 million people worldwide, have drug-resistant hypertension.[2]

Chronic hypertension significantly increases the risk of heart disease, stroke, and kidney disease.[3] While the current primary treatment of the disease is a combination of lifestyle modifications and prescription medication, sometimes the available drug therapies are not sufficient and the blood pressure of patients remains elevated.

Vascular Dynamics is addressing this problem with a novel technology that could offer an alternative treatment option for patients with resistant hypertension. Vascular Dynamics’ MobiusHD®system is currently under evaluation in clinical trials across the USA and Europe.

1. JAMA 2003 289 2560-2571
2. American Heart Association
3. Persell, Stephen D. Hypertension 57.6 (2011): 1076-1080.

What are baroreceptors?

Baroreceptors are nerves located in the aortic arch (near the heart), and the carotid artery sinus (in the neck).

Baroreceptors are part of the body’s natural control mechanism (baroreflex) to regulate blood pressure. When they function normally the baroreflex buffers fluctuations in blood pressure by causing reflex-mediated reciprocal changes in both heart rate and sympathetic nerve activity, thereby keeping the level of arterial pressure at a predetermined operating level.[4]

4. Hypertension 1991 17 72-79

Treating resistant hypertension

Enhancing Baroreflex Response with MobiusHD®

Recognizing the natural physiologic mechanism of the carotid baroreceptors, Vascular Dynamics has developed a minimally invasive, percutaneous approach based on signal amplification to enhance the baroreflex response as a method of treating resistant hypertension.

The investigational MobiusHD® implant is designed to reshape the carotid sinus.

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